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Tooth-derived bone graft material

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±è¿µ±Õ, ÀÌÁØÈ£, ¾öÀοõ, ±è°æ¿í, Murata Masaru, Akazawa Toshiyuki, Mitsugi Masaharu,
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±è¿µ±Õ ( Kim Young-Kyun ) - Seoul National University Bundang Hospital Section of Dentistry Department of Oral and Maxillofacial Surgery
ÀÌÁØÈ£ ( Lee Jun-Ho ) - Korea Tooth Bank
¾öÀοõ ( Um In-Woong ) - Korea Tooth Bank
±è°æ¿í ( Kim Kyung-Wook ) - Dankook University College of Dentistry Department of Oral and Maxillofacial Surgery
 ( Murata Masaru ) - Health Sciences University of Hokkaido Department of Oral and Maxillofacial Surgery
 ( Akazawa Toshiyuki ) - Hokkaido Industrial Research Institute Department of Industrial Technology Research
 ( Mitsugi Masaharu ) - Takamatsu Oral and Maxillofacial Surgery Clinic

Abstract


With successful extraction of growth factors and bone morphogenic proteins (BMPs) from mammalian teeth, many researchers have supported development of a bone substitute using tooth-derived substances. Some studies have also expanded the potential use of teeth as a carrier for growth factors and stem cells. A broad overview of the published findings with regard to tooth-derived regenerative tissue engineering technique is outlined. Considering more than 100 published papers, our team has developed the protocols and techniques for processing of bone graft material using extracted teeth. Based on current studies and studies that will be needed in the future, we can anticipate development of scaffolds, homogenous and xenogenous tooth bone grafts, and dental restorative materials using extracted teeth.

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Tooth; Dentin; Demineralized dentin matrix; Bone substitutes; Tissue engineering

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